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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-BHLHE22 Antibody
Goat anti-BHLHE22 Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q8NFJ8 |
| Other Accession | NP_689627.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | BHLHE22 |
| Calculated MW | 36997 Da |
| Gene ID | 27319 |
|---|---|
| Other Names | BHLHE22; basic helix-loop-helix family, member e22; BHLHB5; Beta3; CAGL85; TNRC20; basic helix-loop-helix domain containing, class B, 5; class B basic helix-loop-helix protein 5; class E basic helix-loop-helix protein 22; trinucleotide repeat containing 2 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-BHLHE22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BHLHE22 |
|---|---|
| Synonyms | BHLHB5, TNRC20 |
| Function | Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Brain-specific, with the highest expression in the cerebellum. |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4453a
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