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KD-Validated Anti-CRTC3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q6UUV7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5935 |
| Calculated MW | Predicted, 67 kDa, observed, 67 kDa |
| Gene Name | CRTC3 |
| Aliases | CRTC3; CREB Regulated Transcription Coactivator 3; CREB-Regulated Transcription Coactivator 3; FLJ21868; TORC-3; TORC3; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3; Transducer Of Regulated CAMP Response Element-Binding Protein 3; Transducer Of Regulated CREB Protein 3; Transducer Of CREB Protein 3 |
| Immunogen | A synthesized peptide derived from CRTC3 |
| Gene ID | 64784 |
|---|---|
| Other Names | CREB-regulated transcription coactivator 3, Transducer of regulated cAMP response element-binding protein 3, TORC-3, Transducer of CREB protein 3, CRTC3, TORC3 |
| Name | CRTC3 |
|---|---|
| Synonyms | TORC3 |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Cellular Location | Nucleus. Cytoplasm. Note=Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118) |
| Tissue Location | Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI1016
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