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> home > Products > Primary Antibodies > Antibody Collections > Skin Melanoma negative > KD-Validated Anti-MCM6 Rabbit Monoclonal Antibody
KD-Validated Anti-MCM6 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14566 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2005 |
| Calculated MW | Predicted, 93 kDa , observed, 93 kDa |
| Gene Name | MCM6 |
| Aliases | MCM6; Minichromosome Maintenance Complex Component 6; Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6; DNA Replication Licensing Factor MCM6; P105MCM; Mis5; MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae); MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe); Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae); MIS5 Homolog (S.Pombe); EC 3.6.4.12; MCG40308; MIS5 |
| Immunogen | A synthesized peptide derived from human MCM6 |
| Gene ID | 4175 |
|---|---|
| Other Names | DNA replication licensing factor MCM6, 3.6.4.12, p105MCM, MCM6 (HGNC:6949) |
| Name | MCM6 (HGNC:6949) |
|---|---|
| Function | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). |
| Cellular Location | Nucleus. Chromosome. Note=Binds to chromatin during G1 and detaches from it during S phase. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1019
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