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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MGEA5 Rabbit Monoclonal Antibody
KD-Validated Anti-MGEA5 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O60502 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6120 |
| Calculated MW | Predicted, 103 kDa ; o bserved, 130 kDa |
| Gene Name | OGA |
| Aliases | OGA; O-GlcNAcase; NCOAT; MEA5; Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase; MGEA5; Meningioma Expressed Antigen 5 (Hyaluronidase); N-Acetyl-Beta-D-Glucosaminidase; Meningioma-Expressed Antigen 5; N-Acetyl-Beta-Glucosaminidase; Beta-N-Acetylglucosaminidase; Beta-N-Acetylhexosaminidase; Protein O-GlcNAcase; Beta-Hexosaminidase; Hyaluronidase In Meningioma; Bifunctional Protein NCOAT; EC 3.2.1.169; KIAA0679; HEXC |
| Immunogen | A synthesized peptide derived from human MGEA5 |
| Gene ID | 10724 |
|---|---|
| Other Names | Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610, ECO:0000305}, OGA, 3.2.1.169, Beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, Beta-hexosaminidase, Meningioma-expressed antigen 5, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase, Nuclear cytoplasmic O-GlcNAcase and acetyltransferase, NCOAT, OGA {ECO:0000303|PubMed:20863279, ECO:0000312|HGNC:HGNC:7056} |
| Name | OGA {ECO:0000303|PubMed:20863279, ECO:0000312|HGNC:HGNC:7056} |
|---|---|
| Function | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta- GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). |
| Cellular Location | [Isoform 3]: Nucleus |
| Tissue Location | Ubiquitous. Shows highest expression in the brain, placenta and pancreas. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1082
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