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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Janus kinase 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Janus kinase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P23458 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2245 |
| Calculated MW | Predicted, 133 kDa , observed, 133 kDa |
| Gene Name | JAK1 |
| Aliases | JAK1; Janus Kinase 1; JAK1A; JAK1B; JTK3; Tyrosine-Protein Kinase JAK1; EC 2.7.10.2; EC 2.7.10; AIIDE; JAK-1 |
| Immunogen | A synthesized peptide derived from human JAK1 |
| Gene ID | 3716 |
|---|---|
| Other Names | Tyrosine-protein kinase JAK1, 2.7.10.2, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B |
| Name | JAK1 |
|---|---|
| Synonyms | JAK1A, JAK1B |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). |
| Cellular Location | Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated |
| Tissue Location | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue |
Research Areas
Citations (0)
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1086
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