KD-Validated Anti-Adenylosuccinate Lyase Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND

Application
| WB, FC |
|---|---|
| Primary Accession | P30566 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 25GB595 |
| Calculated MW | Predicted, 55 kDa, observed, 48 kDa |
| Gene Name | ADSL |
| Aliases | ADSL; Adenylosuccinate Lyase; Adenylosuccinase; EC 4.3.2.2; AMPS; ASL; EC 4.3.2; ASASE; ASase |
| Immunogen | Recombinant protein of human ADSL |
| Gene ID | 158 |
|---|---|
| Other Names | Adenylosuccinate lyase, ADSL, ASL, 4.3.2.2, Adenylosuccinase, ASase, ADSL, AMPS |
| Name | ADSL |
|---|---|
| Synonyms | AMPS |
| Function | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
| Tissue Location | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1 |

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