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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CIRBP Rabbit Monoclonal Antibody
KD-Validated Anti-CIRBP Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14011 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB7980 |
| Calculated MW | Predicted, 19 kDa , observed, 19 kDa |
| Gene Name | CIRBP |
| Aliases | CIRBP; Cold Inducible RNA Binding Protein; CIRP; Cold-Inducible RNA-Binding Protein; Glycine-Rich RNA Binding Protein; A18 HnRNP; Glycine-Rich RNA-Binding Protein CIRP; Cold Inducible RNA-Binding Protein; Testicular Tissue Protein Li 39; A18HNRNP |
| Immunogen | A synthesized peptide derived from CIRBP |
| Gene ID | 1153 |
|---|---|
| Other Names | Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP |
| Name | CIRBP |
|---|---|
| Synonyms | A18HNRNP, CIRP |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. |
| Cellular Location | Nucleus, nucleoplasm. Cytoplasm Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1148
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