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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Core-binding factor subunit beta Rabbit Monoclonal Antibody
KD-Validated Anti-Core-binding factor subunit beta Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q13951 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3785 |
| Calculated MW | Predicted, 22 kDa , observed, 22 kDa |
| Gene Name | CBFB |
| Aliases | CBFB; Core-Binding Factor Subunit Beta; PEBP2B; SL3/AKV Core-Binding Factor Beta Subunit; SL3-3 Enhancer Factor 1 Subunit Beta; Core-Binding Factor Beta Subunit; PEBP2-Beta; PEA2-Beta; CBF-Beta; Polyomavirus Enhancer Binding Protein 2, Beta Subunit; Polyomavirus Enhancer-Binding Protein 2 Beta Subunit; SL3-3 Enhancer Factor 1 Beta Subunit; Core-Binding Factor, Beta Subunit; CLCD2 |
| Immunogen | A synthesized peptide derived from human CBFb |
| Gene ID | 865 |
|---|---|
| Other Names | Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, CBFB |
| Name | CBFB |
|---|---|
| Function | Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T- cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q08024}. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1223
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