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KD-Validated Anti-PVR Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-PVR Rabbit Monoclonal Antibody AGI1276
    Western blotting analysis using anti-PVR antibody (Cat#61508). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-PVR antibody (Cat#61508, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • WB - KD-Validated Anti-PVR Rabbit Monoclonal Antibody AGI1276
    Western blotting analysis using anti-PVR antibody (Cat#61508). PVR expression in wild type (WT) and PVR shRNA knockdown (KD) HeLa cells with 30 µg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-PVR antibody (Cat#61508, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
    detail
  • ICC - KD-Validated Anti-PVR Rabbit Monoclonal Antibody AGI1276
    Immunocytochemical staining of HT-1080 cells with PVR antibody (Cat#61508, 1:1,000). Nuclei were stained blue with DAPI; PVR was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 µm.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, ICC
Primary Accession P15151
Reactivity Human
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 23GB 2575
Calculated MW Predicted, 45 kDa , observed, 70 kDa
Gene Name PVR
Aliases PVR; PVR Cell Adhesion Molecule; Poliovirus Receptor; CD155; NECL5; HVED; PVS; Nectin-Like Protein 5; Necl-5; NECL-5; TAGE4; Nectin-Like 5; CD155 Antigen; Tage4
Immunogen A synthesized peptide derived from human Poliovirus Receptor
Additional Information
Gene ID 5817
Other Names Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
Protein Information
Name PVR
Synonyms PVS
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
Cellular Location [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Beta]: Secreted.
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1276
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