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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Chromobox Rabbit Monoclonal Antibody
KD-Validated Anti-Chromobox Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P45973 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB2865 |
| Calculated MW | Predicted, 22 kDa; observed, 22 kDa |
| Gene Name | CBX5 |
| Aliases | CBX5; Chromobox ; HP1-ALPHA; HP1; Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila); Heterochromatin Protein 1 Homolog Alpha; Chromobox Protein Homolog 5; HP1Hs-Alpha; Antigen P25; HP1alpha; HP1A; Chromobox Homolog 5 (Drosophila HP1 Alpha); Heterochromatin Protein 1-Alpha; HP1 Alpha Homolog (Drosophila); Epididymis Luminal Protein 25; Chromobox Homolog 5; HP1 Alpha Homolog; HP1Hs Alpha; HP1 Alpha; HEL25 |
| Immunogen | A synthesized peptide derived from human HP1 alpha |
| Gene ID | 23468 |
|---|---|
| Other Names | Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A |
| Name | CBX5 |
|---|---|
| Synonyms | HP1A |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). |
| Cellular Location | Nucleus. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346). Localizes to sites of DNA damage (PubMed:28977666) |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1303
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