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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Calsyntenin 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Calsyntenin 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O94985 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3725 |
| Calculated MW | Predicted, 110 kDa , observed, 150 kDa |
| Gene Name | CLSTN1 |
| Aliases | CLSTN1; Calsyntenin 1; KIAA0911; CDHR12; CSTN1; Alzheimer-Related Cadherin-Like Protein; Cadherin-Related Family Member 12; Non-Classical Cadherin XB31alpha; Alcadein-Alpha; Calsyntenin-1; ALC-ALPHA; XB31alpha; Alcalpha1; Alcalpha2; Alc-Alpha; PIK3CD; CST-1; CS1 |
| Immunogen | A synthesized peptide derived from human CLSTN1 |
| Gene ID | 22883 |
|---|---|
| Other Names | Calsyntenin-1, Alcadein-alpha, Alc-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha, Soluble Alc-alpha, SAlc-alpha, CTF1-alpha, C-terminal fragment 1-alpha, CLSTN1 (HGNC:17447) |
| Name | CLSTN1 (HGNC:17447) |
|---|---|
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cell projection, neuron projection. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses {ECO:0000250|UniProtKB:Q9EPL2} |
| Tissue Location | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1350
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