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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Mitotic Arrest Deficient 1 Like 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Mitotic Arrest Deficient 1 Like 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y6D9 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3060 |
| Calculated MW | Predicted, 83 kDa; observed, 75 kDa |
| Gene Name | MAD1L1 |
| Aliases | MAD1L1; Mitotic Arrest Deficient 1 Like 1; TXBP181; MAD1; HsMAD1; TP53I9; PIG9; Mitotic Spindle Assembly Checkpoint Protein MAD1; Mitotic Arrest Deficient 1-Like Protein 1; Mitotic Checkpoint MAD1 Protein Homolog; MAD1 Mitotic Arrest Deficient Like 1; Tax-Binding Protein 181; MAD1-Like Protein 1; MAD1 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 1; Mitotic-Arrest Deficient 1, Yeast, Homolog-Like 1; MAD1 Mitotic Arrest Deficient-Like 1 (Yeast); Tumor Protein P53 Inducible Protein 9; HMAD1; MVA7 |
| Immunogen | A synthesized peptide derived from human MAD1 |
| Gene ID | 8379 |
|---|---|
| Other Names | Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181, MAD1L1, MAD1, TXBP181 |
| Name | MAD1L1 |
|---|---|
| Synonyms | MAD1, TXBP181 |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Co- localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:18981471, PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720) Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). |
| Tissue Location | [Isoform 1]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level) |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1352
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