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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Transcription Factor 7 Like 2 Rabbit Monoclonal Antibody
KD-Validated Anti-Transcription Factor 7 Like 2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9NQB0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3275 |
| Calculated MW | Predicted, 68 kDa; observed, 68 kDa |
| Gene Name | TCF7L2 |
| Aliases | TCF7L2; Transcription Factor 7 Like 2; TCF-4; TCF4; Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box); T-Cell-Specific Transcription Factor 4; HMG Box Transcription Factor 4; Transcription Factor 7-Like 2; T-Cell Factor 4; HTCF-4 |
| Immunogen | A synthesized peptide derived from human TCF7L2 |
| Gene ID | 6934 |
|---|---|
| Other Names | Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2, TCF4 |
| Name | TCF7L2 |
|---|---|
| Synonyms | TCF4 |
| Function | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. |
| Cellular Location | Nucleus, PML body. Nucleus. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies |
| Tissue Location | Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1379
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