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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > KD-Validated Anti-Oxoglutarate receptor 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Oxoglutarate receptor 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96P68 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4575 |
| Calculated MW | Predicted, 38 kDa , observed, 36 kDa |
| Gene Name | OXGR1 |
| Aliases | OXGR1; Oxoglutarate Receptor 1; P2RY15; P2Y15; Alpha-Ketoglutarate Receptor 1; 2-Oxoglutarate Receptor 1; GPR80; GPR99; AKGR; Oxoglutarate (Alpha-Ketoglutarate) Receptor 1; G Protein-Coupled Receptor 80; G-Protein Coupled Receptor 99; P2Y-Like Nucleotide Receptor; P2Y Purinoceptor 15; P2Y-Like GPCR; Seven Transmembrane Helix Receptor; G-Protein Coupled Receptor 80; CAON2 |
| Immunogen | A synthesized peptide derived from human OXGR1 / GPR99 |
| Gene ID | 27199 |
|---|---|
| Other Names | 2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y15, P2Y-like GPCR, P2Y-like nucleotide receptor, OXGR1 |
| Name | OXGR1 |
|---|---|
| Function | G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:36571463, PubMed:36919698). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity) (PubMed:15141213). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner |
| Tissue Location | Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1457
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