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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-WD repeat domain 1 Rabbit Monoclonal Antibody
KD-Validated Anti-WD repeat domain 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O75083 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4720 |
| Calculated MW | Predicted, 66 kDa, observed, 75 kDa |
| Gene Name | WDR1 |
| Aliases | WDR1; WD Repeat Domain 1; AIP1; Actin-Interacting Protein 1; WD Repeat-Containing Protein 1; NORI-1; Epididymis Secretory Protein Li 52; HEL-S-52; PFITS |
| Immunogen | A synthesized peptide derived from human WDR1 |
| Gene ID | 9948 |
|---|---|
| Other Names | WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1, WDR1 |
| Name | WDR1 |
|---|---|
| Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome. Cell junction |
| Tissue Location | Expressed in peripheral blood mononuclear cells (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI1471
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