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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Emerin Rabbit Monoclonal Antibody
KD-Validated Anti-Emerin Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P50402 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5320 |
| Calculated MW | Predicted, 29 kDa , observed, 29 kDa |
| Gene Name | EMD |
| Aliases | EMD; Emerin; STA; LEMD5; LEM Domain Containing 5; EDMD; Emery-Dreifuss Muscular Dystrophy |
| Immunogen | A synthesized peptide derived from human Emerin |
| Gene ID | 2010 |
|---|---|
| Other Names | Emerin, EMD, EDMD, STA |
| Name | EMD |
|---|---|
| Synonyms | EDMD, STA |
| Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
| Cellular Location | Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus |
| Tissue Location | Skeletal muscle, heart, colon, testis, ovary and pancreas |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1517
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