KD-Validated Anti-Glutamic-oxaloacetic transaminase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, FC |
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Primary Accession | P17174 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Isotype | Rabbit IgG |
Clone Names | 23GB5585 |
Calculated MW | Predicted, 46 kDa , observed, 47 kDa |
Gene Name | GOT1 |
Aliases | GOT1; Glutamic-Oxaloacetic Transaminase 1; Glutamate Oxaloacetate Transaminase 1; AST1; SGOT; AST; Glutamic-Oxaloacetic Transaminase 1, Soluble; Aspartate Aminotransferase, Cytoplasmic; Cysteine Aminotransferase, Cytoplasmic; Cysteine Transaminase, Cytoplasmic; Aspartate Aminotransferase 1; Aspartate Transaminase 1; Transaminase A; EC 2.6.1.1; CAspAT; CCAT; Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1); Testis Secretory Sperm-Binding Protein Li 196a; Growth-Inhibiting Protein 18; EC 2.6.1.3; ASTQTL1; GIG18 |
Immunogen | A synthesized peptide derived from human Aspartate Aminotransferase |
Gene ID | 2805 |
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Other Names | Aspartate aminotransferase, cytoplasmic, cAspAT, 2.6.1.1, 2.6.1.3, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A, GOT1 (HGNC:4432) |
Name | GOT1 (HGNC:4432) |
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Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2- aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). |
Cellular Location | Cytoplasm. |

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