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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Galectin 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Galectin 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P09382 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB6025 |
| Calculated MW | Predicted, 15 kDa , observed , 14 kDa |
| Gene Name | LGALS1 |
| Aliases | LGALS1; Galectin 1; GBP; Lectin, Galactoside-Binding, Soluble, 1; Beta-Galactoside-Binding Lectin L-14-I; Putative MAPK-Activating Protein PM12; 14 KDa Laminin-Binding Protein; Lactose-Binding Lectin 1; S-Lac Lectin 1; 14 KDa Lectin; Galectin-1; Galaptin; HLBP14; Gal-1; HBL; HPL; Epididymis Secretory Sperm Binding Protein; Beta-Galactoside-Binding Protein 14kDa; Lectin Galactoside-Binding Soluble 1; GAL1 |
| Immunogen | A synthesized peptide derived from human Galectin 1 |
| Gene ID | 3956 |
|---|---|
| Other Names | Galectin-1, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, LGALS1 (HGNC:6561) |
| Name | LGALS1 (HGNC:6561) |
|---|---|
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Cytoplasm. Secreted Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion. |
| Tissue Location | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1547
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