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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-E2F transcription factor 1 Rabbit Monoclonal Antibody
KD-Validated Anti-E2F transcription factor 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q01094 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1505 |
| Calculated MW | Predicted, 4 7 kDa , observed, 65 kDa |
| Gene Name | E2F1 |
| Aliases | E2F1; E2F Transcription Factor 1; RBBP3; RBP3; Retinoblastoma-Binding Protein 3 (E2F-Like); Retinoblastoma-Associated Protein 1; Retinoblastoma-Binding Protein 3; Transcription Factor E2F1; PRB-Binding Protein E2F-1; RBAP-1; RBBP-3; E2F-1; PBR3; RBAP1 |
| Immunogen | A synthesized peptide derived from human E2F1 |
| Gene ID | 1869 |
|---|---|
| Other Names | Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113} |
| Name | E2F1 {ECO:0000303|PubMed:8964493, ECO:0000312|HGNC:HGNC:3113} |
|---|---|
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53- dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). |
| Cellular Location | Nucleus |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1572
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