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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Methyl-CpG Binding Domain Protein 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Methyl-CpG Binding Domain Protein 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9UIS9 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB405 |
| Calculated MW | Predicted, 67 kDa , o bserved , 70-80 kDa |
| Gene Name | MBD1 |
| Aliases | MBD1; Methyl-CpG Binding Domain Protein 1; CXXC3; PCM1; Protein Containing Methyl-CpG-Binding Domain 1; Methyl-CpG-Binding Domain Protein 1; CXXC-Type Zinc Finger Protein 3; Protein Containing MBD 1; The Regulator Of Fibroblast Growth Factor 2 (FGF-2) Transcription; Methyl-CpG-Binding Protein MBD1; RFT |
| Immunogen | A synthesized peptide derived from human MBD1 |
| Gene ID | 4152 |
|---|---|
| Other Names | Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, MBD1 (HGNC:6916), CXXC3, PCM1 |
| Name | MBD1 (HGNC:6916) |
|---|---|
| Synonyms | CXXC3, PCM1 |
| Function | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. |
| Cellular Location | Nucleus. Nucleus matrix. Nucleus speckle Chromosome Note=Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10454587, PubMed:10648624). |
| Tissue Location | Widely expressed.. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1605
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