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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Rab4 Rabbit Monoclonal Antibody
KD-Validated Anti-Rab4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P20338 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB825 |
| Calculated MW | Predicted, 24 kDa , observed , 24 kDa |
| Gene Name | RAB4A |
| Aliases | RAB4A, Member RAS Oncogene Family; HRES-1/RAB4; RAB4; Ras-Related Protein Rab-4A; HTLV-1 Related Endogenous Sequence; EC 3.6.5.2; HRES-1; HRES1 |
| Immunogen | A synthesized peptide derived from human Rab4 |
| Gene ID | 5867 |
|---|---|
| Other Names | Ras-related protein Rab-4A, 3.6.5.2, RAB4A (HGNC:9781), RAB4 |
| Name | RAB4A (HGNC:9781) |
|---|---|
| Synonyms | RAB4 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). |
| Cellular Location | Membrane; Peripheral membrane protein. Cytoplasm Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1 |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1628
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