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> home > Products > Primary Antibodies > Antibody Collections > Pancreas negative > KD-Validated Anti-PICALM Rabbit Monoclonal Antibody
KD-Validated Anti-PICALM Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q13492 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1620 |
| Calculated MW | Predicted, 71 kDa , observed, 71,69,66 kDa |
| Gene Name | PICALM |
| Aliases | Phosphatidylinositol Binding Clathrin Assembly Protein; CALM; CLTH; Phosphatidylinositol-Binding Clathrin Assembly Protein; Clathrin Assembly Lymphoid Myeloid Leukemia Protein; LAP |
| Immunogen | A synthesized peptide derived from human PICALM |
| Gene ID | 8301 |
|---|---|
| Other Names | Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein, PICALM, CALM |
| Name | PICALM |
|---|---|
| Synonyms | CALM |
| Function | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R- SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM- dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP- CTF) (PubMed:24067654, PubMed:25241929). |
| Cellular Location | Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin- coated vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119) |
| Tissue Location | Expressed in all tissues examined. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1696
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