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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ubiquitination Factor E4B Rabbit Monoclonal Antibody
KD-Validated Anti-Ubiquitination Factor E4B Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O95155 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1765 |
| Calculated MW | Predicted, 146 kDa , observed , 130 kDa |
| Gene Name | UBE4B |
| Aliases | UBE4B; Ubiquitination Factor E4B; UFD2; KIAA0684; UBOX3; E4; Ubiquitination Factor E4B (UFD2 Homolog, Yeast); RING-Type E3 Ubiquitin Transferase E4 B; Ubiquitin Conjugation Factor E4 B; HDNB1; Ubiquitination Factor E4B (Homologous To Yeast UFD2); Homozygously Deleted In Neuroblastoma-1; Homozygously Deleted In Neuroblastoma 1; Ubiquitin-Fusion Degradation Protein 2; Ubiquitin Fusion Degradation Protein 2; Homologous To Yeast UFD2; EC 2.3.2.27; UFD2A |
| Immunogen | A synthesized peptide derived from human UBE4B |
| Gene ID | 10277 |
|---|---|
| Other Names | Ubiquitin conjugation factor E4 B, 2.3.2.27, UBE4B (HGNC:12500) |
| Name | UBE4B (HGNC:12500) |
|---|---|
| Function | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q9ES00} |
| Tissue Location | Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788) |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1716
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