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> home > Products > Primary Antibodies > Antibody Collections > Pancreas negative > KD-Validated Anti-Transmembrane Protein 43 Rabbit Monoclonal Antibody
KD-Validated Anti-Transmembrane Protein 43 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9BTV4 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2325 |
| Calculated MW | Predicted, 45 kDa , observed , 42 kDa |
| Gene Name | TMEM43 |
| Aliases | TMEM43; Transmembrane Protein 43; LUMA; DKFZp586G1919; MGC3222; ARVD5; Arrhythmogenic Right Ventricular Dysplasia 5; EDMD7; AUNA2; Protein LUMA; ARVC5; AUNA3; EDMD7 |
| Immunogen | A synthesized peptide derived from human TMEM43 |
| Gene ID | 79188 |
|---|---|
| Other Names | Transmembrane protein 43, Protein LUMA, TMEM43 |
| Name | TMEM43 |
|---|---|
| Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020). |
| Cellular Location | Endoplasmic reticulum membrane. Nucleus inner membrane; Multi-pass membrane protein. Cell membrane Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). |
| Tissue Location | Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1741
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