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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-UBE2L3 Rabbit Monoclonal Antibody
KD-Validated Anti-UBE2L3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P68036 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1875 |
| Calculated MW | Predicted, 18 kDa , observed , 17 kDa |
| Gene Name | UBE2L3 |
| Aliases | UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin-Conjugating Enzyme E2 L3; E2 Ubiquitin-Conjugating Enzyme L3; Ubiquitin-Conjugating Enzyme E2-F1; Ubiquitin Carrier Protein L3; Ubiquitin-Protein Ligase L3; L-UBC; Ubiquitin-Conjugating Enzyme E2L 3; Ubiquitin Conjugating Enzyme E2L 3; Ubiquitin-Conjugating Enzyme UBCH7; EC 2.3.2.23; EC 6.3.2.19; E2-F1; UbcM4; UBCE7; UbcH7 |
| Immunogen | A synthesized peptide derived from human UBE2L3 |
| Gene ID | 7332 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 L3, 2.3.2.23, E2 ubiquitin-conjugating enzyme L3, L-UBC, UbcH7, Ubiquitin carrier protein L3, Ubiquitin-conjugating enzyme E2-F1, Ubiquitin-protein ligase L3, UBE2L3, UBCE7, UBCH7 |
| Name | UBE2L3 |
|---|---|
| Synonyms | UBCE7, UBCH7 |
| Function | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine; in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex (PubMed:38605244). In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Ubiquitous, with highest expression in testis. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1759
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