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KD-Validated Anti-LDL Receptor Related Protein 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q07954 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB4945 |
| Calculated MW | Predicted, 505 kDa, observed, 85 kDa |
| Gene Name | LRP1 |
| Aliases | LRP1; LDL Receptor Related Protein 1; APOER; Alpha-2-Macroglobulin Receptor; IGFBP3R1; IGFBP-3R; LRP1A; CD91; A2Human, rat; LRP; APR; Prolow-Density Lipoprotein Receptor-Related Protein 1; Low Density Lipoprotein Receptor-Related Protein 1; Apolipoprotein E Receptor; Transforming Growth Factor-β Receptor Type V; TbetaR-V/LRP-1/IGFBP-3 Receptor; Type V Tgf-Beta Receptor; CD91 Antigen; EC 3.4.21.9; EC 1.1.1.94; IGFBP3R; TGFBR5; LRP-1; KPA |
| Immunogen | A synthesized peptide derived from human LRP1 |
| Gene ID | 4035 |
|---|---|
| Other Names | Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1 (HGNC:6692), A2MR, APR |
| Name | LRP1 (HGNC:6692) |
|---|---|
| Synonyms | A2MR, APR |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371). |
| Cellular Location | [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. |
| Tissue Location | Most abundant in liver, brain and lung. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1869
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