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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Pro-Apoptotic WT1 Regulator Rabbit Monoclonal Antibody
KD-Validated Anti-Pro-Apoptotic WT1 Regulator Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96IZ0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5010 |
| Calculated MW | Predicted, 37 kDa, observed, 41 kDa |
| Gene Name | PAWR |
| Aliases | PAWR; Pro-Apoptotic WT1 Regulator; Par-4; PAR4; PRKC Apoptosis WT1 Regulator Protein; PRKC, Apoptosis, WT1, Regulator; Prostate Apoptosis Response-4; Prostate Apoptosis Response Protein PAR-4; Prostate Apoptosis Response Protein 4; Prostate Apoptosis Response 4 Protein; Transcriptional Repressor PAR4; WT1-Interacting Protein |
| Immunogen | A synthesized peptide derived from human PAR4 |
| Gene ID | 5074 |
|---|---|
| Other Names | PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4, PAWR, PAR4 |
| Name | PAWR |
|---|---|
| Synonyms | PAR4 |
| Function | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti- apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| Cellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. |
| Tissue Location | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1874
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