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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Glutaredoxin 3 Mouse Monoclonal Antibody
KD-Validated Anti-Glutaredoxin 3 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O76003 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB13145 |
| Calculated MW | Predicted, 37 kDa, observed, 38 kDa |
| Gene Name | GLRX3 |
| Aliases | GLRX3; Glutaredoxin 3; PICOT; GLRX4; TXNL2; GRX3; GRX4; PKC-Interacting Cousin Of Thioredoxin; PKC-Theta-Interacting Protein; Thioredoxin-Like Protein 2; PKCq-Interacting Protein; Glutaredoxin 4; Glutaredoxin-3; BA500G10.4; Testicular Tissue Protein Li 75; Thioredoxin-Like 2; TXNL3 |
| Immunogen | Recombinant protein of human GLRX3 |
| Gene ID | 10539 |
|---|---|
| Other Names | Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT {ECO:0000303|PubMed:10636891}, TXNL2 |
| Name | GLRX3 |
|---|---|
| Synonyms | PICOT {ECO:0000303|PubMed:10636891}, TXN |
| Function | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9CQM9}. Note=Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250|UniProtKB:Q9CQM9} |
| Tissue Location | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine |
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$ 149.00
$ 499.00
Cat# AGI2069
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