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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Sirtuin 5 Mouse Monoclonal Antibody
KD-Validated Anti-Sirtuin 5 Mouse Monoclonal Antibody
Mouse monoclonal antibody
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9NXA8 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13235 |
| Calculated MW | Predicted, 34 kDa, observed, 30 kDa |
| Gene Name | SIRT5 |
| Aliases | SIRT5; Sirtuin 5; NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial; SIR2L5; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae); Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5; NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial; Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5; NAD-Dependent Deacetylase Sirtuin-5; Regulatory Protein SIR2 Homolog 5; SIR2-Like Protein 5; Sirtuin Type 5; Sir2-Like 5; EC 2.3.1.- |
| Immunogen | Recombinant protein of human SIRT5 |
| Gene ID | 23408 |
|---|---|
| Other Names | NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}, 2.3.1.- {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24703693, ECO:0000269|PubMed:29180469}, Regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIR2-like protein 5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIRT5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIR2L5 |
| Name | SIRT5 {ECO:0000255|HAMAP-Rule:MF_03160} |
|---|---|
| Synonyms | SIR2L5 |
| Function | NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| Cellular Location | Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus [Isoform 2]: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562} |
| Tissue Location | Widely expressed.. |
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$ 149.00
$ 499.00
Cat# AGI2080
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