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> home > Products > Primary Antibodies > Antibody Collections > Thyroid gland positive > KD-Validated Anti-NAE1 Mouse Monoclonal Antibody
KD-Validated Anti-NAE1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q13564 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB13290 |
| Calculated MW | Predicted, 60 kDa, observed, 60 kDa |
| Gene Name | NAE1 |
| Aliases | NAE1; NEDD8 Activating Enzyme E1 Subunit 1; APP-BP1; APPBP1; Ula-1; Amyloid Beta Precursor Protein-Binding Protein 1, 59 KDa ; Amyloid Beta Precursor Protein Binding Protein 1, 59kDa; NEDD8-Activating Enzyme E1 Regulatory Subunit; Amyloid Protein-Binding Protein 1; Proto-Oncogene Protein 1; Amyloid Beta Precursor Protein-Binding Protein 1, 59kD; NEDD8-Activating Enzyme E1 Subunit; Protooncogene Protein 1; A-116A10.1; NEDFIH; HPP1 |
| Immunogen | Recombinant protein of human NAE1 |
| Gene ID | 8883 |
|---|---|
| Other Names | NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1 |
| Name | NAE1 |
|---|---|
| Synonyms | APPBP1 |
| Function | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. |
| Cellular Location | Cell membrane. Note=Colocalizes with APP in lipid rafts |
| Tissue Location | Ubiquitous in fetal tissues. Expressed throughout the adult brain. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2087
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