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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CLIC4 Rabbit Polyclonal Antibody
KD-Validated Anti-CLIC4 Rabbit Polyclonal Antibody
Rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y696 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | Predicted, 29 kDa, observed, 28 kDa |
| Gene Name | CLIC4 |
| Aliases | CLIC4; Chloride Intracellular Channel 4; CLIC4L; P64H1; HuH1; H1; Intracellular Chloride Ion Channel Protein P64H1; Chloride Intracellular Channel Protein 4; Glutaredoxin-Like Oxidoreductase CLIC4; DKFZP566G223; Epididymis Secretory Sperm Binding Protein; Chloride Intracellular Channel 4 Like; EC 1.8.-.-; MTCLIC |
| Immunogen | A synthesized peptide derived from human CLIC4 |
| Gene ID | 25932 |
|---|---|
| Other Names | Chloride intracellular channel protein 4, Glutaredoxin-like oxidoreductase CLIC4, 1.8.-.-, Intracellular chloride ion channel protein p64H1, CLIC4 {ECO:0000303|PubMed:12163372, ECO:0000312|HGNC:HGNC:13518} |
| Name | CLIC4 {ECO:0000303|PubMed:12163372, ECO:0000312|HGNC:HGNC:13518} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0W7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0W7}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596} |
| Tissue Location | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2147
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