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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-UHRF2 Mouse Monoclonal Antibody
KD-Validated Anti-UHRF2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96PU4 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB14330 |
| Calculated MW | Predicted, 90kDa, observed, 95 kDa |
| Gene Name | UHRF2 |
| Aliases | UHRF2; Ubiquitin Like With PHD And Ring Finger Domains 2; RNF107; NIRF; TDRD23; URF2; Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein Ligase; Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 2; Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 2; RING-Type E3 Ubiquitin Transferase UHRF2; Np95/ICBP90-Like RING Finger Protein; E3 Ubiquitin-Protein Ligase UHRF2; Np95-Like Ring Finger Protein; RING Finger Protein 107; Nuclear Protein 97; MGC33463; Ubiquitin-Like, Containing PHD And RING Finger Domains, 2; Nuclear Zinc Finger Protein NP97; Nuclear Zinc Finger Protein Np97; Np95-Like RING Finger Protein; EC 2.3.2.27; EC 6.3.2 |
| Immunogen | Recombinant protein of human UHRF2 |
| Gene ID | 115426 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase UHRF2, 2.3.2.27, Np95/ICBP90-like RING finger protein, Np95-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, RING finger protein 107, RING-type E3 ubiquitin transferase UHRF2, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains protein 2, UHRF2, NIRF, RNF107 |
| Name | UHRF2 |
|---|---|
| Synonyms | NIRF, RNF107 |
| Function | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751}. Chromosome. Note=Enriched at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC) |
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$ 149.00
$ 499.00
Cat# AGI2184
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