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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CPSF6 Rabbit Monoclonal Antibody
KD-Validated Anti-CPSF6 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q16630 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB145 |
| Calculated MW | Predicted, 59 kDa; observed, 68 kDa |
| Gene Name | CPSF6 |
| Aliases | CPSF6; Cleavage And Polyadenylation Specific Factor 6; CFIM68; Cleavage Factor Im Complex 68 KDa Subunit; HPBRII-4; HPBRII-7; CFIM72; CFIM; Cleavage And Polyadenylation Specificity Factor 68 KDa Subunit; Cleavage And Polyadenylation Specificity Factor Subunit 6; Cleavage And Polyadenylation Specific Factor 6, 68kDa; Pre-MRNA Cleavage Factor Im 68 KDa Subunit; CPSF 68 KDa Subunit; Protein HPBRII-4/7; Cleavage And Polyadenylation Specific Factor 6, 68kD Subunit; Pre-MRNA Cleavage Factor I, 68kD Subunit; Pre-MRNA Cleavage Factor Im (68kD); CFIm68 |
| Immunogen | A synthesized peptide derived from human CPSF6 |
| Gene ID | 11052 |
|---|---|
| Other Names | Cleavage and polyadenylation specificity factor subunit 6, Cleavage and polyadenylation specificity factor 68 kDa subunit, CPSF 68 kDa subunit, Cleavage factor Im complex 68 kDa subunit, CFIm68, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7, CPSF6 (HGNC:13871) |
| Name | CPSF6 (HGNC:13871) |
|---|---|
| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'- UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). |
| Cellular Location | Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules (PubMed:17267687). Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status (PubMed:30916345). |
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$ 149.00
$ 499.00
Cat# AGI2201
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