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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NAMPT Rabbit Monoclonal Antibody
KD-Validated Anti-NAMPT Rabbit Monoclonal Antibody
Rabbit monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P43490 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB255 |
| Calculated MW | Predicted, 56 kDa, observed, 50 kDa |
| Gene Name | NAMPT |
| Aliases | NAMPT; Nicotinamide Phosphoribosyltransferase; PBEF; Visfatin; PBEF1; Pre-B-Cell Colony-Enhancing Factor 1; Pre-B Cell-Enhancing Factor; EC 2.4.2.12; NAmPRTase; Pre-B-Cell Colony Enhancing Factor 1; 1110035O14Rik; Nampt; VF |
| Immunogen | A synthesized peptide derived from human Visfatin |
| Gene ID | 10135 |
|---|---|
| Other Names | Nicotinamide phosphoribosyltransferase, NAmPRTase, Nampt, 2.4.2.12, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin, NAMPT, PBEF, PBEF1 |
| Name | NAMPT |
|---|---|
| Synonyms | PBEF, PBEF1 |
| Function | Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1- mediated suppression (By similarity). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100- fold higher concentrations compared to maternal serum |
| Tissue Location | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2214
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