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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-HEXIM1 Mouse Monoclonal Antibody
KD-Validated Anti-HEXIM1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O94992 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 25GB650 |
| Calculated MW | Predicted, 41 kDa; observed, 63 kDa |
| Gene Name | HEXIM1 |
| Aliases | HEXIM1; HEXIM P-TEFb Complex Subunit 1; HIS1; MAQ1; EDG1; Hexamethylene Bis-Acetamide-Inducible Protein 1; Hexamethylene Bisacetamide Inducible 1; Estrogen Down-Regulated Gene 1 Protein; Cardiac Lineage Protein 1; Menage A Quatre Protein 1; Protein HEXIM1; CLP-1; CLP1; Hexamethylene-Bis-Acetamide-Inducible Transcript 1; Hexamethylene Bisacetamide-Inducible Protein; Hexamethylene Bis-Acetamide Inducible 1; Hexamthylene Bis-Acetamide Inducible 1; Menage A Quatre 1; HMBA-Inducible |
| Immunogen | Recombinant protein of human HEXIM1 |
| Gene ID | 10614 |
|---|---|
| Other Names | Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1 |
| Name | HEXIM1 |
|---|---|
| Synonyms | CLP1, EDG1, HIS1, MAQ1 |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
| Cellular Location | Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050) |
| Tissue Location | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2221
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