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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-SLBP Rabbit Monoclonal Antibody
KD-Validated Anti-SLBP Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q14493 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4485 |
| Calculated MW | Predicted, 31 kDa; observed, 37 kDa |
| Gene Name | SLBP |
| Aliases | SLBP; Stem-Loop Histone MRNA Binding Protein; HBP; Stem-Loop (Histone) Binding Protein; Histone RNA Hairpin-Binding Protein; Stem-Loop Binding Protein; Histone Binding Protein; Histone Stem-Loop Binding Protein; Histone Stem-Loop-Binding Protein; Hairpin Binding Protein, Histone |
| Immunogen | A synthesized peptide derived from human SLBP |
| Gene ID | 7884 |
|---|---|
| Other Names | Histone RNA hairpin-binding protein, Histone stem-loop-binding protein, SLBP, HBP |
| Name | SLBP |
|---|---|
| Synonyms | HBP |
| Function | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=Polyribosome-associated (PubMed:12588979). Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase (PubMed:12588979). Through the S phase, partially redistributes to the cytoplasm (PubMed:12588979) Binding to histone mRNA is necessary for cytoplasmic localization (PubMed:12588979). Shuttles between the nucleus and the cytoplasm (PubMed:15829567). Imported in the nucleus by the Importin alpha/Importin beta receptor (PubMed:15829567) |
| Tissue Location | Widely expressed.. |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI2267
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