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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-TEAD4 Rabbit Monoclonal Antibody
KD-Validated Anti-TEAD4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15561 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4515 |
| Calculated MW | Predicted, 48 kDa; observed, 54 kDa |
| Gene Name | TEAD4 |
| Aliases | TEAD4; TEA Domain Transcription Factor 4; TEA Domain Family Member 4; TCF13L1; TEFR-1; EFTR-2; TEF-3; Transcriptional Enhancer Factor TEF-3; Transcriptional Enhancer Factor 3; Transcription Factor 13-Like 1; Transcription Factor RTEF-1; RTEF-1; RTEF1; TEF3; Transcriptional Enhancer Factor 1-Related; Related Transcription Enhancer Factor 1B; HRTEF-1B; TEAD-4 |
| Immunogen | Recombinant protein of human TEAD4 |
| Gene ID | 7004 |
|---|---|
| Other Names | Transcriptional enhancer factor TEF-3, TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1, TEAD4, RTEF1, TCF13L1, TEF3 |
| Name | TEAD4 |
|---|---|
| Synonyms | RTEF1, TCF13L1, TEF3 |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. |
| Cellular Location | Nucleus. |
| Tissue Location | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2273
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