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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-VPS41 Rabbit Monoclonal Antibody
KD-Validated Anti-VPS41 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P49754 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4595 |
| Calculated MW | Predicted, 99 kDa; observed, 99 kDa |
| Gene Name | VPS41 |
| Aliases | VPS41; VPS41 Subunit Of HOPS Complex; HVSP41; Vacuolar Protein Sorting-Associated Protein 41 Homolog; VPS41, HOPS Complex Subunit; S53; Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae); Vacuolar Protein Sorting 41 (Yeast Homolog); Vacuolar Protein Sorting 41 (Yeast); Vacuolar Protein Sorting 41 Homolog; Vacuolar Assembly Protein 41; HVps41p; HVPS41; SCAR29 |
| Immunogen | A synthesized peptide derived from human VPS41 |
| Gene ID | 27072 |
|---|---|
| Other Names | Vacuolar protein sorting-associated protein 41 homolog, S53, VPS41 |
| Name | VPS41 |
|---|---|
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5- to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:23167963, PubMed:25445562, PubMed:25908847, PubMed:9159129). Required for fusion of autophagosomes with lysosomes (PubMed:25783203, PubMed:37821429). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:21802320, PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). |
| Cellular Location | Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytosol |
| Tissue Location | Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells. |
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$ 149.00
$ 499.00
Cat# AGI2279
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