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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-PRKRA Rabbit Monoclonal Antibody
KD-Validated Anti-PRKRA Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | O75569 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2340 |
| Calculated MW | Predicted, 34 kDa ; Observed, 34 kDa |
| Gene Name | PRKRA |
| Aliases | PRKRA; Protein Activator Of Interferon Induced Protein Kinase EIF2AK2; PACT; RAX; Protein Activator Of The Interferon-Induced Protein Kinase; PKR-Associated Protein X ; HSD14 ; DYT16; Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase Activator A; Protein Kinase, Interferon-Inducible Double-Stranded RNA-Dependent Activator; PKR-Associating Protein X; Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator |
| Immunogen | A synthesized peptide derived from human PRKRA |
| Gene ID | 8575 |
|---|---|
| Other Names | Interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X, PKR-associating protein X, Protein activator of the interferon-induced protein kinase, Protein kinase, interferon-inducible double-stranded RNA-dependent activator, PRKRA, PACT, RAX |
| Name | PRKRA |
|---|---|
| Synonyms | PACT, RAX |
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2320
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