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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Hexokinase 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Hexokinase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P19367 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB870 |
| Calculated MW | Predicted, 102 kDa, observed, 102 kDa |
| Gene Name | HK1 |
| Aliases | Brain Form Hexokinase; Hexokinase Type I; Hexokinase-1; Hexokinase-A; EC 2.7.1.1; Neuropathy, Hereditary Motor And Sensory, Russe Type; Glycolytic Enzyme; Hexokinase IR; Hexokinase; EC 2.7.1; NEDVIBA; HK1-Ta; HK1-Tb; HK1-Tc; HMSNR; HXK1; NMSR; RP79; HK I; HKD; HKI; HK |
| Immunogen | A synthesized peptide derived from human Hexokinase 1 |
| Gene ID | 3098 |
|---|---|
| Other Names | Hexokinase-1, 2.7.1.1, Brain form hexokinase, Hexokinase type I, HK I, Hexokinase-A, HK1 (HGNC:4922) |
| Name | HK1 (HGNC:4922) |
|---|---|
| Function | Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). |
| Cellular Location | Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331). |
| Tissue Location | Isoform 2: Erythrocyte specific (Ref.6). Isoform 3: Testis-specific (PubMed:10978502). Isoform 4: Testis-specific (PubMed:10978502). {ECO:0000269|PubMed:10978502, ECO:0000269|Ref.6} |
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$ 149.00
$ 499.00
Cat# AGI2361
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