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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-FERMT2 Mouse Monoclonal Antibody
KO-Validated Anti-FERMT2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q96AC1 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 24GB6195 |
| Calculated MW | Predicted, 78 kDa, observed, 73 kDa |
| Gene Name | FERMT2 |
| Aliases | FERMT2; FERM Domain Containing Kindlin 2; KIND2; UNC112B; PLEKHC1; Mig-2; Pleckstrin Homology Domain Containing, Family C (With FERM Domain) Member 1; PH Domain-Containing Family C Member 1; Fermitin Family Homolog 2; Mitogen Inducible Gene-2; Fermitin Family Member 2; Kindlin-2; MIG2; Pleckstrin Homology Domain Containing, Family C Member 1; Pleckstrin Homology Domain-Containing Family C Member 1; Fermitin Family Homolog 2 (Drosophila); Mitogen Inducible Gene 2 Protein; Mitogen-Inducible Gene 2 Protein; Kindlin 2; UNC112; MIG-2 |
| Immunogen | Recombinant protein of human FERMT2 |
| Gene ID | 10979 |
|---|---|
| Other Names | Fermitin family homolog 2, Kindlin-2, Mitogen-inducible gene 2 protein, MIG-2, Pleckstrin homology domain-containing family C member 1, PH domain-containing family C member 1, FERMT2, KIND2, MIG2, PLEKHC1 |
| Name | FERMT2 |
|---|---|
| Synonyms | KIND2, MIG2, PLEKHC1 |
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Cellular Location | Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides |
| Tissue Location | Ubiquitous. Found in numerous tumor tissues. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2401
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