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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-Syntaxin 17 Mouse Monoclonal Antibody
KO-Validated Anti-Syntaxin 17 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P56962 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB15925 |
| Calculated MW | Predicted, 33 kDa, observed, 34 kDa |
| Gene Name | STX17 |
| Aliases | STX17; Syntaxin 17; Syntaxin-17; FLJ20651 |
| Immunogen | Recombinant protein of human STX17 |
| Gene ID | 55014 |
|---|---|
| Other Names | Syntaxin-17, STX17 {ECO:0000303|PubMed:21545355, ECO:0000312|HGNC:HGNC:11432} |
| Name | STX17 {ECO:0000303|PubMed:21545355, ECO:0000312|HGNC:HGNC:11432} |
|---|---|
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158} Mitochondrion membrane; Multi-pass membrane protein. Autolysosome membrane; Multi-pass membrane protein. Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). Colocalized with RAB39A and RAB39B in autolysosomes in autophagy-induced conditions (PubMed:37821429). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2415
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