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STX17 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - STX17 Antibody (N-term) AP13599a
    STX17 Antibody (N-term) (Cat. #AP13599a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the STX17 antibody detected the STX17 protein (arrow).
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  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P56962
Other Accession Q9Z158, Q9D0I4, Q5E9Y2, NP_060389.2
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33403 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 55014
Other Names Syntaxin-17, STX17
Target/Specificity This STX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STX17.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTX17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STX17 {ECO:0000303|PubMed:21545355, ECO:0000312|HGNC:HGNC:11432}
Function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158} Mitochondrion membrane; Multi-pass membrane protein. Note=Has a hairpin-like insertion into membranes Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709).
Research Areas
Citations ( 0 )

Background

Implicated in vesicle trafficking to lysosomes. STX17 could be involved in processes related to cell division (By similarity).

References

Petukhova, L., et al. Nature 466(7302):113-117(2010)
Zhao, Z.Z., et al. Melanoma Res. 19(2):80-86(2009)
Steegmaier, M., et al. Mol. Biol. Cell 11(8):2719-2731(2000)
Steegmaier, M., et al. J. Biol. Chem. 273(51):34171-34179(1998)

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$ 365.00
$ 140.00
Cat# AP13599a
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