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CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone HNK-1 or Leu-7 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF |
|---|---|
| Primary Accession | Q9P2W7 |
| Other Accession | 27087, 381050 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM, kappa |
| Clone Names | HNK-1 or Leu-7 |
| Calculated MW | ~110kDa |
| Gene ID | 27087 |
|---|---|
| Other Names | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, 2.4.1.135, Beta-1, 3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | B3GAT1 (HGNC:921) |
|---|---|
| Synonyms | GLCATP |
| Function | Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. |
| Cellular Location | [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35789}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O35789}. Secreted {ECO:0000250|UniProtKB:O35789} |
| Tissue Location | Mainly expressed in the brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Anti-CD57 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5, and CEA.
References
Abo T et. al. J Immunol, 1982, 129(4):1758-61. | Abo T et al. J Immunology, 1982, 129:1752-7
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