CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 203.6]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, FC |
---|---|
Primary Accession | P26842 |
Other Accession | 939, 355307 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | Mouse / IgG3, kappa |
Clone Names | 203.6 |
Calculated MW | 120kDa |
Gene ID | 939 |
---|---|
Other Names | CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7 |
Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
Precautions | CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD27 |
---|---|
Synonyms | TNFRSF7 |
Function | Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Found in most T-lymphocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27 (Workshop VI; Code 6T-028). CD27 is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.
References
Kishimoto T et al. (eds) Leukocyte Typing VI. P67-71, Garland Publishing, New York, 1997
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