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CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone 203.6]

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P26842
Other Accession 939, 355307
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG3, kappa
Clone Names 203.6
Calculated MW 120kDa
Additional Information
Gene ID 939
Other Names CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD27
Synonyms TNFRSF7
Function Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Found in most T-lymphocytes.
Research Areas
Citations (0)
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Background

Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27 (Workshop VI; Code 6T-028). CD27 is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.

References

Kishimoto T et al. (eds) Leukocyte Typing VI. P67-71, Garland Publishing, New York, 1997

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$ 219.00
$ 499.00
Cat# AH12677-20
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