CLDN4 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O14493 |
Other Accession | O14493, NP_001296, NM_001305 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Sheep, Bovine |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Sheep, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22 kDa |
Gene ID | 1364 |
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Alias Symbol | CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R |
Other Names | Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8 |
Target/Specificity | This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CLDN4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CLDN4 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLDN4 |
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Function | Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:O35054}. Cell membrane; Multi-pass membrane protein. Note=CLDN4 is required for tight junction localization in the kidney. {ECO:0000250|UniProtKB:O35054} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a rabbit polyclonal antibody against CLDN4. It was validated on Western Blot by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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