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TNRC6A antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NDV7 |
| Other Accession | NM_014494, NP_055309 |
| Reactivity | Human, Mouse, Horse, Dog |
| Predicted | Mouse, Rat, Chicken, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 210kDa |
| Gene ID | 27327 |
|---|---|
| Alias Symbol | CAGH26, DKFZp666E117, FLJ22043, GW1, GW182, KIAA1460, MGC75384, TNRC6 |
| Other Names | Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa, TNRC6A, CAGH26, KIAA1460, TNRC6 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TNRC6A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TNRC6A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNRC6A |
|---|---|
| Synonyms | CAGH26, KIAA1460, TNRC6 |
| Function | Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. |
| Cellular Location | Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs) |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
References
Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). WB, H, Mouse, Human, Dog22898980
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