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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > RTN4 antibody - middle region
RTN4 antibody - middle region
Rabbit Polyclonal Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NQC3 |
| Other Accession | NM_207520, NP_997403 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Sheep, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Gene ID | 57142 |
|---|---|
| Alias Symbol | ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C |
| Other Names | Reticulon-4, Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5, RTN4, KIAA0886, NOGO |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RTN4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RTN4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTN4 (HGNC:14085) |
|---|---|
| Function | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). |
| Cellular Location | [Isoform A]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Cytoplasmic side Synapse {ECO:0000250|UniProtKB:Q99P72}. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977) Co-localizes with TMEM33 at the ER sheets [Isoform C]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Isoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:21183689). Isoform C: is expressed in brain, skeletal muscle and adipocytes. Isoform D is testis-specific. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Hu,F.(2008)J.Neurosci.28(5),1262-1269ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.Publications:Beetz,C.etal.AspasticparaplegiamousemodelrevealsREEP1-dependentERshaping.J.Clin.Invest.123,4273-82(2013).WB,Human,Bovine,Dog,Rat,Horse,Rabbit,Sheep,Pig,Mouse,Guineapig,Zebrafish24051375
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$ 389.00
Cat# AI12714
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