|Other Accession||NM_010757, NP_034887|
|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Bovine|
|Alias Symbol||AW061068, NF-E2, Nfe2u|
|Other Names||Transcription factor MafK, Erythroid transcription factor NF-E2 p18 subunit, Mafk, Nfe2u|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mafk antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mafk antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity).|
|Tissue Location||Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells|
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