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IMP5 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8IUH8 |
| Other Accession | NM_175882, NP_787078 |
| Reactivity | Human, Yeast |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74kDa |
| Gene ID | 162540 |
|---|---|
| Alias Symbol | SPPL2c, IMP5 |
| Other Names | Signal peptide peptidase-like 2C, SPP-like 2C, SPPL2c, 3.4.23.-, Intramembrane protease 5, IMP-5, SPPL2C, IMP5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-IMP5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | IMP5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPPL2C (HGNC:28902) |
|---|---|
| Function | Sperm-specific intramembrane-cleaving aspartic protease (I- CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side |
| Tissue Location | Highly expressed in testis where it is primarily localised in spermatids (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Grigorenko A.P.,et al.Biochemistry (Mosc.) 67:826-834(2002).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Friedmann E.,et al.J. Biol. Chem. 279:50790-50798(2004).
Friedmann E.,et al.Nat. Cell Biol. 8:843-848(2006).
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